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You can lean into this with a lifegain commander like Ayli, Eternal Pilgrim, Sorin of House Markov, or Karlov of the Ghost Council, and you can amplify your opponents life loss with effects like Wound Reflection and Warlock Class

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When Perilous Myr is put into a graveyard from the battlefield, it deals 2 damage to target creature or player

Lets be fair, though, Esper isnt really the color combination for giving all your creatures a lot of power, so if you want to steal your opponents fattest creatures, youre going to need ways to pump your team

You can also set whatever prices youd like for the items youre selling, though youll want to remain within reason and base your prices at least somewhat on general market prices

Youre not necessarily gonna be destroying anything so costly that gaining that much life will make a huge difference